MicroRNA-124 suppresses oral squamous cell carcinoma motility by targeting ITGB1

被引：140

作者：

Hunt, Stuart ^{[1
]}

Jones, Adam V. ^{[1
]}

Hinsley, Emma E. ^{[1
]}

Whawell, Simon A. ^{[1
]}

Lambert, Daniel W. ^{[1
]}

机构：

[1] Univ Sheffield, Sch Clin Dent, Oral Dis Res Grp, Sheffield S10 2TA, S Yorkshire, England

来源：

FEBS LETTERS | 2011年 / 585卷 / 01期

关键词：

miR-124; Integrin beta-1; Oral cancer; Invasion; EXPRESSION; INVASION; MIR-124;

D O I：

10.1016/j.febslet.2010.11.038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alterations in the levels of molecules which interact with the extracellular matrix, such as integrins, are associated with invasion of oral squamous cell carcinomas (OSCC). The molecular mechanisms underlying dysregulation of integrin expression in OSCC, however, remain unclear. Here, we show that microRNA-124, a small non-coding RNA down-regulated in OSCC, is able to downregulate expression of integrin beta-1 (ITGB1) by interacting with its 3' untranslated region. Over-expression of miR-124 attenuates endogenous ITGB1 expression and reduces the adherence and motility of OSCC cells, suggesting disruption of miR-124-mediated repression of ITGB1 may be a key factor in OSCC progression. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

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页码：187 / 192

页数：6

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