Synthesis of α-substituted N-aryl acrylamide derivatives through Baylis-Hillman reaction

被引：20

作者：

Guo, W ^{[1
]}

Wu, WW ^{[1
]}

Fan, NJ ^{[1
]}

Wu, ZG ^{[1
]}

Xia, CZ ^{[1
]}

机构：

[1] Shanxi Univ, Sch Chem & Chem Engn, Taiyuan 030006, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2005年 / 35卷 / 09期

基金：

中国国家自然科学基金;

关键词：

aromatic aldehyde; Baylis-Hillman reaction; N-aryl acrylamide;

D O I：

10.1081/SCC-200054850

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-aryl acrylamides were found to be the more activated Michael acceptor for Baylis-Hillman reaction than acrylamides and N-alkyl acrylamides. Treatment of N-aryl acrylamides with aromatic aldehydes in the presence of DABCO (1,4-diazabicyclo[2-2.2]octane) afforded the desired Baylis-Hillman products, alpha-substituted acrylamide derivatives, which have important applications as novel radical polymerization monomers and biologically important reagents.

引用

页码：1239 / 1251

页数：13

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