Event-related wave activity in the EEG provides new marker of ADHD

被引：33

作者：

Alexander, David M. ^{[1
,2
,3
]}

Hermens, Daniel F. ^{[4
]}

Keage, Hannah A. D. ^{[5
]}

Clark, C. Richard ^{[5
]}

Williams, Leanne M. ^{[4
,6
]}

Kohn, Michael R. ^{[4
,7
,8
]}

Clarke, Simon D. ^{[4
,6
,7
]}

Lamb, Chris ^{[9
]}

Gordon, Evian ^{[2
,4
,6
]}

机构：

[1] RIKEN, Lab Perceptual Dynam, Brain Sci Inst, Wako, Saitama 3510198, Japan

[2] Brain Resource Co, Brain Resource Int Database, Sydney, NSW, Australia

[3] UTS, Fac Informat Technol, Sydney, NSW, Australia

[4] Westmead Hosp, Westmead Millennium Inst, Brain Dynam Ctr, Sydney, NSW, Australia

[5] Flinders Univ S Australia, Sch Psychol, Cognit Neurosci Lab, Adelaide, SA 5001, Australia

[6] Westmead Hosp, Western Cllin Sch, Sydney, NSW, Australia

[7] Westmead Hosp, CRASH, Sydney, NSW, Australia

[8] Childrens Hosp Westmead, Sydney, NSW, Australia

[9] Womens & Childrens Hosp, Child Dev Unit, Adelaide, SA, Australia

来源：

CLINICAL NEUROPHYSIOLOGY | 2008年 / 119卷 / 01期

关键词：

EEG; ADHD; phase dynamics; hyperactivity/impulsivity; stimulant medication;

D O I：

10.1016/j.clinph.2007.09.119

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective:: This study examines the utility of new measures of event-related spatio-temporal waves in the EEG as a marker of ADHD, previously shown to be closely related to the P3 ERP in an adult sample. Methods: Wave activity in the EEG was assessed during both an auditory Oddball and a visual continuous performance task (CPT) for an ADHD group ranging in age from 6 to 18 years and comprising mostly Combined and Inattentive subtypes, and for an age and gender matched control group. Results: The ADHD subjects had less wave activity at low frequencies (similar to 1 Hz) during both tasks. For auditory Oddball targets, this effect was shown to be related to smaller P3 ERP amplitudes. During CPT, the similar to 1 Hz wave activity in the ADHD subjects was inversely related to clinical and behavioral measures of hyperactivity and impulsivity. CPT wave activity at similar to 1 Hz was seen to "normalise" following treatment with stimulant medication. Conclusions: The results identify a deficit in low frequency wave activity as a new marker for ADHD associated with levels of hyperactivity and impulsivity. Significance: The marker is evident across a range of tasks and may be specific to ADHD. While lower similar to 1 Hz activity partly accounts for reduced P3 ERPs in ADHD, the effect also arises for tasks that do not elicit a P3. Deficits in behavioral inhibition are hypothesized to arise from underlying dysregulation of cortical inhibition. Crown copyright (c) 2007 Published by Elsevier Ireland Ltd on behalf of International Federation of Clinical Neurophysiology. All rights reserved.

引用

页码：163 / 179

页数：17

共 84 条

[1]

Alexander D, 2006, Acta Neuropsychiatr, V18, P240, DOI 10.1111/j.1601-5215.2006.00158.x

[2] The contribution of apolipoprotein E alleles on cognitive performance and dynamic neural activity over six decades [J].

Alexander, D. M. ;

Williams, L. M. ;

Gatt, J. M. ;

Dobson-Stone, C. ;

Kuan, S. A. ;

Todd, E. G. ;

Schofield, P. R. ;

Cooper, N. J. ;

Gordon, E. .

BIOLOGICAL PSYCHOLOGY, 2007, 75 (03) :229-238

[3] Measurement of phase gradients in the EEG [J].

Alexander, D. M. ;

Trengove, C. ;

Wright, J. J. ;

Boord, P. R. ;

Gordon, E. .

JOURNAL OF NEUROSCIENCE METHODS, 2006, 156 (1-2) :111-128

[4]

Alexander David M., 2006, Journal of Integrative Neuroscience, V5, P49, DOI 10.1142/S0219635206001021

[5]

ALEXANDER DM, 2006, CLIN EEG NEUROSCI, V7, P144

[6] Multichannel auditory event-related brain potentials: Effects of normal aging on the scalp distribution of N1, P2, N2 and P300 latencies and amplitudes [J].

Anderer, P ;

Semlitsch, HV ;

Saletu, B .

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1996, 99 (05) :458-472

[7]

[Anonymous], [No title captured]

[8] Role of locus coeruleus in attention and behavioral flexibility [J].

Aston-Jones, G ;

Rajkowski, J ;

Cohen, J .

BIOLOGICAL PSYCHIATRY, 1999, 46 (09) :1309-1320

[9] THE SPOT-THE-WORD TEST - A ROBUST ESTIMATE OF VERBAL INTELLIGENCE BASED ON LEXICAL DECISION [J].

BADDELEY, A ;

EMSLIE, H ;

NIMMOSMITH, I .

BRITISH JOURNAL OF CLINICAL PSYCHOLOGY, 1993, 32 :55-65

[10] Behavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD [J].

Barkley, RA .

PSYCHOLOGICAL BULLETIN, 1997, 121 (01) :65-94

← 1 2 3 4 5 6 7 8 9 →