Practical aspects of the oral new anticoagulants

被引：22

作者：

DeLoughery, Thomas G. ^{[1
,2
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Med, Div Hematol Med Oncol, Portland, OR 97201 USA

[2] Oregon Hlth & Sci Univ, Dept Pathol, Div Lab Med, Portland, OR 97201 USA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2011年 / 86卷 / 07期

关键词：

RECOMBINANT FACTOR-VIIA; PROTHROMBIN COMPLEX CONCENTRATE; FACTOR XA INHIBITOR; VENOUS THROMBOEMBOLISM; DABIGATRAN ETEXILATE; ATRIAL-FIBRILLATION; DOUBLE-BLIND; THROMBIN INHIBITOR; KNEE REPLACEMENT; BLEEDING-TIME;

D O I：

10.1002/ajh.22021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

After years of only oral vitamin K antagonists, there are new many new antithrombotic agents in development and on entering the marketplace. This review will analyze clinical trial results for these new agents-especially dibigatran, rivaroxaban, and apixiban. Also to be discussed are practical aspects of use of these new agents such monitoring, reversal, and use before procedures. Am. J. Hematol. 86:586-590, 2011. (C) 2011 Wiley-Liss, Inc.

引用

页码：586 / 590

页数：5

共 41 条

[1]

[Anonymous], 2011, ROCKET AF

[2] Warfarin Versus New Agents: Interpreting the Data [J].

Ansell, Jack .

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 2010, :221-228

[3] Oral Rivaroxaban for Symptomatic Venous Thromboembolism. [J].

Bauersachs, Rupert ;

Berkowitz, Scott D. ;

Brenner, Benjamin ;

Buller, Harry R. ;

Decousus, Herve ;

Gallus, Alex S. ;

Lensing, Anthonie W. ;

Misselwitz, Frank ;

Prins, Martin H. ;

Raskob, Gary E. ;

Segers, Annelise ;

Verhamme, Peter ;

Wells, Phil ;

Agnelli, Giancarlo ;

Bounameaux, Henri ;

Cohen, Alexander ;

Davidson, Bruce L. ;

Piovella, Franco ;

Schellong, Sebastian .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (26) :2499-2510

[4] Ability of recombinant factor VIIa to reverse the anticoagulant effect of the pentasaccharide fondaparinux in healthy volunteers [J].

Bijsterveld, NR ;

Moons, AH ;

Boekholdt, SM ;

van Aken, BE ;

Fennema, H ;

Peters, RJG ;

Meijers, JCM ;

Büller, HR ;

Levi, M .

CIRCULATION, 2002, 106 (20) :2550-2554

[5] Apixaban in Patients with Atrial Fibrillation [J].

Connolly, Stuart J. ;

Eikelboom, John ;

Joyner, Campbell ;

Diener, Hans-Christoph ;

Hart, Robert ;

Golitsyn, Sergey ;

Flaker, Greg ;

Avezum, Alvaro ;

Hohnloser, Stefan H. ;

Diaz, Rafael ;

Talajic, Mario ;

Zhu, Jun ;

Pais, Prem ;

Budaj, Andrzej ;

Parkhomenko, Alexander ;

Jansky, Petr ;

Commerford, Patrick ;

Tan, Ru San ;

Sim, Kui-Hian ;

Lewis, Basil S. ;

Van Mieghem, Walter ;

Lip, Gregory Y. H. ;

Kim, Jae Hyung ;

Lanas-Zanetti, Fernando ;

Gonzalez-Hermosillo, Antonio ;

Dans, Antonio L. ;

Munawar, Muhammad ;

O'Donnell, Martin ;

Lawrence, John ;

Lewis, Gayle ;

Afzal, Rizwan ;

Yusuf, Salim .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (09) :806-817

[6] Dabigatran versus Warfarin in Patients with Atrial Fibrillation. [J].

Connolly, Stuart J. ;

Ezekowitz, Michael D. ;

Yusuf, Salim ;

Eikelboom, John ;

Oldgren, Jonas ;

Parekh, Amit ;

Pogue, Janice ;

Reilly, Paul A. ;

Themeles, Ellison ;

Varrone, Jeanne ;

Wang, Susan ;

Alings, Marco ;

Xavier, Denis ;

Zhu, Jun ;

Diaz, Rafael ;

Lewis, Basil S. ;

Darius, Harald ;

Diener, Hans-Christoph ;

Joyner, Campbell D. ;

Wallentin, Lars .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (12) :1139-1151

[7]

DIEHL KH, 1995, HAEMOSTASIS, V25, P182

[8]

Diener HC, 2010, LANCET NEUROL, V9, P1157, DOI 10.1016/S1474-4422(10)70274-X

[9] Effects of agents, used to treat bleeding disorders, on bleeding time prolonged by a very high dose of a direct thrombin inhibitor in anesthesized rats and rabbits [J].

Elg, M ;

Carlsson, S ;

Gustafsson, D .

THROMBOSIS RESEARCH, 2001, 101 (03) :159-170

[10] Effect of activated prothrombin complex concentrate or recombinant factor VIIa on the bleeding time and thrombus formation during anticoagulation with a direct thrombin inhibitor [J].

Elg, M ;

Carlsson, S ;

Gustafsson, D .

THROMBOSIS RESEARCH, 2001, 101 (03) :145-157

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