The proto-oncogene c-myb is expressed in sporadic bovine lymphoma, but not in enzootic bovine leukosis

被引：2

作者：

Asahina, M

Ishiguro, N

Wu, DL

Goryo, M

Davis, WC

Okada, K

机构：

[1] OBIHIRO UNIV AGR & VET MED,DEPT VET PUBL HLTH,OBIHIRO,HOKKAIDO 080,JAPAN

[2] WASHINGTON STATE UNIV,COLL VET MED,DEPT VET MICROBIOL & PATHOL,PULLMAN,WA 99164

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 1996年 / 58卷 / 12期

关键词：

c-myb; enzootic bovine leukosis; phenotype; sporadic bovine lymphoma;

D O I：

10.1292/jvms.58.12_1169

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

We examined bovine c-myb gene expression in six samples of sporadic bovine lymphomas (two calf, three thymic and one intermediate) and five of enzootic bovine leukosis. Tumor cells of the sporadic bovine lymphomas were of immature cell lineage (one B lymphoma and five T lymphomas). The c-myb mRNA was expressed in almost all the sporadic bovine lymphomas (except for one thymic form) including a BoCD8 single positive T lymphoma. On the contrary, c-myb was not expressed in mature B lymphomas of enzootic bovine leukosis. The results suggest that c-myb expression is closely associated with tumor cell differentiation of bovine lymphomas.

引用

收藏

页码：1169 / 1174

页数：6

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