Epidemiology of Bladder Cancer

被引：162

作者：

Malats, Nuria ^{[1
]}

Real, Francisco X. ^{[2
,3
]}

机构：

[1] Spanish Natl Canc Res Ctr CNIO, Genet & Mol Epidemiol Grp, Madrid 28029, Spain

[2] Spanish Natl Canc Res Ctr CNIO, Epithelial Carcinogenesis Grp, Madrid 28029, Spain

[3] Univ Pompeu Fabra, Dept Expt & Hlth Sci, Barcelona 08003, Spain

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2015年 / 29卷 / 02期

关键词：

Bladder cancer; Urothelium; Incidence and prevalence; Smoking; Occupational risk factors; Arsenic; Genetic susceptibility; GENOME-WIDE ASSOCIATION; NAT2 SLOW ACETYLATION; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; DISINFECTION BY-PRODUCTS; POPULATION-BASED COHORT; N-ACETYLTRANSFERASE; CONFERS SUSCEPTIBILITY; UROTHELIAL CARCINOMA; REPRODUCTIVE FACTORS; SEQUENCE VARIANT;

D O I：

10.1016/j.hoc.2014.10.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Bladder cancer incidence is higher in old men, shows geographic variation, and is mostly an environmental disease. Cigarette smoking, occupational exposures, water arsenic, Schistosoma haematobium infestation, and some medications are the best established risk factors. Low-penetrance genetic factors also contribute to its origin, some through interaction with environmental factors. Bladder cancer has high prevalence and a low mortality, being largely a chronic disease. Data on environmental and genetic factors involved in the disease outcome are inconclusive.

引用

页码：177 / +

页数：14

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