Inhibition of class D β-lactamases by acyl phosphates and phosphonates

被引:21
作者
Adediran, SA
Nukaga, M
Baurin, S
Frère, JM
Pratt, RF [1 ]
机构
[1] Wesleyan Univ, Dept Chem, Middletown, CT 06459 USA
[2] Jyosai Int Univ, Fac Pharmaceut Sci, Togane, Chiba 2838555, Japan
[3] Univ Liege, Ctr Ingn Prot, B-4000 Sart Tilman Par Liege, Belgium
[4] Univ Liege, Lab Enzymol, B-4000 Sart Tilman Par Liege, Belgium
关键词
D O I
10.1128/AAC.49.10.4410-4412.2005
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The susceptibility of typical class D beta-lactamases to inhibition by acyl phosph(on)ates has been determined. To a large degree, these class D enzymes behaved very similarly to the class A TEM beta-lactamase towards these reagents. Dibenzoyl phosphate stood out in both cases as a lead compound towards a new class of effective inhibitors.
引用
收藏
页码:4410 / 4412
页数:3
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