DNA sequence representation without degeneracy

被引:109
作者
Yau, SST
Wang, JS
Niknejad, A
Lu, C
Jin, N
Ho, YK
机构
[1] Univ Illinois, Dept Math Stat & Comp Sci, Chicago, IL 60607 USA
[2] Univ Illinois, Dept Biochem & Mol Biol, Chicago, IL 60607 USA
[3] Nanjing Univ, Dept Math, Nanjing 210008, Peoples R China
关键词
D O I
10.1093/nar/gkg432
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Graphical representation of DNA sequence provides a simple way of viewing, sorting and comparing various gene structures. A new two-dimensional graphical representation method using a two-quadrant Cartesian coordinates system has been derived for mathematical denotation of DNA sequence. The two-dimensional graphic representation resolves sequences' degeneracy and is mathematically proven to eliminate circuit formation. Given x-projection and y-projection of any point on the graphical representation, the number of A, G, C and T from the beginning of the sequence to that point could be found. Compared with previous methods, this graphical representation is more inline with the conventional recognition of linear sequences by molecular biologists, and also provides a metaphor in two dimensions for local and global DNA sequence comparison.
引用
收藏
页码:3078 / 3080
页数:3
相关论文
共 8 条
[1]   SIMPLER DNA-SEQUENCE REPRESENTATIONS [J].
GATES, MA .
NATURE, 1985, 316 (6025) :219-219
[2]   A SIMPLE WAY TO LOOK AT DNA [J].
GATES, MA .
JOURNAL OF THEORETICAL BIOLOGY, 1986, 119 (03) :319-328
[3]  
HAMORI E, 1983, J BIOL CHEM, V258, P1318
[4]   NOVEL DNA-SEQUENCE REPRESENTATIONS [J].
HAMORI, E .
NATURE, 1985, 314 (6012) :585-585
[5]  
HAMORI E, 1994, FRONTIERS SCI VISUAL, P91
[6]   Some notes on 2-D graphical representation of DNA sequence [J].
Liu, YC ;
Guo, XF ;
Xu, J ;
Pan, LQ ;
Wang, SY .
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 2002, 42 (03) :529-533
[7]  
Nandy A, 1996, COMPUT APPL BIOSCI, V12, P55
[8]   On 3-D graphical representation of DNA primary sequences and their numerical characterization [J].
Randic, M ;
Vracko, M ;
Nandy, A ;
Basak, SC .
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 2000, 40 (05) :1235-1244