Linkage disequilibrium for different scales and applications

被引：115

作者：

Mueller, JC ^{[1
]}

机构：

[1] GSF Natl Res Inst, Inst Human Genet, D-85764 Neuherberg, Germany

来源：

BRIEFINGS IN BIOINFORMATICS | 2004年 / 5卷 / 04期

关键词：

D O I：

10.1093/bib/5.4.355

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Assessing the patterns of linkage disequilibrium (LD) has become an important issue in both evolutionary biology and medical genetics since the rapid accumulation of densely spaced DNA sequence variation data in several organisms. LD deals with the correlation of genetic variation at two or more loci or sites in the genome within a given population. There are a variety of LD measures which range from traditional pairwise LD measures such as D' or r(2) to entropybased multi-locus measures or haplotype-specific approaches. Understanding the evolutionary forces (in particular recombination) that generate the observed variation of LD patterns across genomic regions is addressed by model-based LD analysis. Marker type and its allelic composition also influence the observed LD pattern, microsatellites having a greater power to detect LD in population isolates than SNPs. This review aims to explain basic LD measures and their application properties.

引用

页码：355 / 364

页数：10

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