Fe(II)-Catalyzed Amination of Aromatic C-H Bonds via Ring Opening of 2H-Azirines: Synthesis of 213-Disubstituted Indoles

被引：132

作者：

Jana, Samaresh ^{[1
]}

Clements, Mack D. ^{[1
]}

Sharp, Barry K. ^{[1
]}

Zheng, Nan ^{[1
]}

机构：

[1] Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 17期

关键词：

REARRANGEMENT; ANILINES;

D O I：

10.1021/ol101130e

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

A general method for the synthesis of 2,3-disubstituted indoles is described. The key feature of this method is the amination of aromatic C-H bonds via FeCl2-catalyzed ring opening of 2H-azirines. The method tolerates a variety of functional groups such as Br, F, NO2, OMe, CF3, OTBS, alkenes, and OPiv. The method can also be extended to synthesize azaindoles.

引用

页码：3736 / 3739

页数：4

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