Serum and Cerebrospinal Fluid Levels of Colistin in Pediatric Patients

被引：64

作者：

Antachopoulos, Charalampos ^{[1
]}

Karvanen, Matti ^{[2
]}

Iosifidis, Elias ^{[1
]}

Jansson, Britt ^{[3
]}

Plachouras, Diamantis ^{[4
]}

Cars, Otto ^{[2
]}

Roilides, Emmanuel ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, Dept Pediat 3, GR-54006 Thessaloniki, Greece

[2] Uppsala Univ, Dept Med Sci, Uppsala, Sweden

[3] Uppsala Univ, Dept Pharmaceut Biosci, Uppsala, Sweden

[4] Univ Athens, Sch Med, Dept Internal Med 4, GR-11527 Athens, Greece

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 09期

关键词：

METHANESULFONATE; PLASMA;

D O I：

10.1128/AAC.01799-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Using a liquid chromatography-tandem mass spectrometry method, the serum and cerebrospinal fluid (CSF) concentrations of colistin were determined in patients aged 11/2 months to 14 years receiving intravenous colistimethate sodium (60,000 to 225,000 IU/kg of body weight/day). Only in one of five courses studied (a 14-year-old receiving 225,000 IU/kg/day) did serum concentrations exceed the 2 mu g/ml CLSI/EUCAST breakpoint defining susceptibility to colistin for Pseudomonas and Acinetobacter. CSF colistin concentrations were <0.2 mu g/ml but increased in the presence of meningitis (similar to 0.5 mu g/ml or 34 to 67% of serum levels).

引用

页码：3985 / 3987

页数：3

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