Generation and mapping of Mus spretus strain-specific markers for rapid genomic scanning

被引：10

作者：

Elango, R

Riba, L

Housman, D

Hunter, K

机构：

[1] Center for Cancer Research, Massachusetts Inst. of Technology, Cambridge

来源：

MAMMALIAN GENOME | 1996年 / 7卷 / 05期

关键词：

D O I：

10.1007/s003359900099

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe here a set of generic markers, based on IRS-PCR amplification difference, that are specifically designed for efficient, high throughput genetic mapping in [(M. domesticus x wild-derived) F-1 x M. domesticus] interspecific backcrosses. 146 new genetic loci have been mapped, and strain distribution for these markers has been determined in 96 mouse strains. 103 (81%) of 127 tested markers are present only in one or more wild-derived strains, but absent in 76 other commonly used strains, demonstrating their utility in a variety of mouse pair combinations. Because of the ease of genotyping with this marker set, rapid genome scans for complex genetic trait loci involving crosses between wild-derived strains and other commonly used strains can now be carried out efficiently with large numbers of animals.

引用

页码：340 / 343

页数：4

共 17 条

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