Secondary structure of an armadillo single repeat from the APC protein

被引:13
作者
Hirschl, D
Bayer, P
Muller, O
机构
[1] MAX PLANCK INST MOLEK PHYSIOL,ABT STRUKTURELLE BIOL,D-44139 DORTMUND,GERMANY
[2] MAX PLANCK INST MOLEK PHYSIOL,BIOPHYS CHEM ABT,D-44139 DORTMUND,GERMANY
关键词
H-1-NMR; nuclear overhauser effect; APC protein; armadillo repeat;
D O I
10.1016/0014-5793(96)00215-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The armadillo domain is a repeating sequence motif of a variety of proteins with different functions. Here we describe the structure of a synthetic single armadillo repeat solved by two-dimensional nuclear magnetic resonance spectroscopy. Our results indicate alpha-helical secondary structural elements in half of the residues.
引用
收藏
页码:31 / 36
页数:6
相关论文
共 34 条
  • [1] Single amino acid substitutions in proteins of the armadillo gene family abolish their binding to alpha-catenin
    Aberle, H
    Schwartz, H
    Hoschuetzky, H
    Kemler, R
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (03) : 1520 - 1526
  • [2] SELECTION OF COHERENCE-TRANSFER PATHWAYS IN NMR PULSE EXPERIMENTS
    BODENHAUSEN, G
    KOGLER, H
    ERNST, RR
    [J]. JOURNAL OF MAGNETIC RESONANCE, 1984, 58 (03) : 370 - 388
  • [3] LOCALIZATION OF THE GENE FOR FAMILIAL ADENOMATOUS POLYPOSIS ON CHROMOSOME-5
    BODMER, WF
    BAILEY, CJ
    BODMER, J
    BUSSEY, HJR
    ELLIS, A
    GORMAN, P
    LUCIBELLO, FC
    MURDAY, VA
    RIDER, SH
    SCAMBLER, P
    SHEER, D
    SOLOMON, E
    SPURR, NK
    [J]. NATURE, 1987, 328 (6131) : 614 - 616
  • [4] BRUNGER AT, 1992, XPLOR 3 1 MANUAL
  • [5] CONFORMATIONAL PARAMETERS FOR AMINO-ACIDS IN HELICAL, BETA-SHEET, AND RANDOM COIL REGIONS CALCULATED FROM PROTEINS
    CHOU, PY
    FASMAN, GD
    [J]. BIOCHEMISTRY, 1974, 13 (02) : 211 - 222
  • [6] GANS PJ, 1991, BIOPOLYMERS, V31, P1606
  • [7] FURTHER DEVELOPMENTS OF PROTEIN SECONDARY STRUCTURE PREDICTION USING INFORMATION-THEORY - NEW PARAMETERS AND CONSIDERATION OF RESIDUE PAIRS
    GIBRAT, JF
    GARNIER, J
    ROBSON, B
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1987, 198 (03) : 425 - 443
  • [8] CLEAN TOCSY FOR H-1 SPIN SYSTEM-IDENTIFICATION IN MACROMOLECULES
    GRIESINGER, C
    OTTING, G
    WUTHRICH, K
    ERNST, RR
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (23) : 7870 - 7872
  • [9] HERRMANN F, 1995, NDEE NMR SOFTWARE PA
  • [10] ULTRAVIOLET CIRCULAR DICHROISM OF POLYPEPTIDES
    HOLZWARTH, G
    DOTY, P
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1965, 87 (02) : 218 - +