The inhibitory effect of nitrite, a stable product of nitric oxide (NO) formation, on arginase

被引：41

作者：

Hrabak, A

Bajor, T

Temesi, A

Meszaros, G

机构：

[1] Department of Medical Chemistry, Molec. Biol. and Pathobiochemistry, Semmelweis University Medical School, H-1444 Budapest

来源：

FEBS LETTERS | 1996年 / 390卷 / 02期

关键词：

arginase; NO synthase; nitrite; inhibition; fluorescence; macrophage;

D O I：

10.1016/0014-5793(96)00659-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macrophages contain arginase and an inducible NO synthase, demonstrated by using L-arginine, the common substrate, for production of both nitric oxide and urea, Arginase was inhibited by nitrite, the stable end product of NO, This inhibition was non-competitive, and could not be explained by the reaction of nitrite with arginine, or by the irreversible covalent modification of arginase, or by the removal of Mn2+, a cofactor of arginase.

引用

页码：203 / 206

页数：4

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