Intramolecular amination catalysed by ruthenium and palladium. Synthesis of 2-acyl indoles and 2-aryl quinolines by carbonylation of 2-nitrochalcones

被引:25
作者
Cenini, S [1 ]
Bettettini, E [1 ]
Fedele, M [1 ]
Tollari, S [1 ]
机构
[1] CTR CNR,I-20133 MILAN,ITALY
关键词
amination; carbonylation; palladium; ruthenium; 2-acyl indoles; 2-arylquinolines;
D O I
10.1016/1381-1169(96)00123-9
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
The carbonylation in toluene of 2-nitrochalcones at 20 bar and 100 degrees C, with Pd(TMB)(2) as catalyst and TMPhen as cocatalyst (TMBH = 2,4,6-trimethyl benzoic acid; TMPhen = 3,4,7,8-tetramethyl-1,10-phenanthroline) gave the corresponding 2-acyl indoles in 60-98% yields. The use as catalyst of Ru-3(CO)(12) activated by a rigid alpha-diimine ligand such as DIAN-Me((*)), in ethanol-water, at 30 bar and 170 degrees C, gave a mixture of the corresponding acyl indoles and quinolines, the latter being usually the most abundant products.
引用
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页码:37 / 41
页数:5
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