Creating a Framework for Conducting Randomized Clinical Trials during Disease Outbreaks

被引：57

作者：

Dean, Natalie E. ^{[1
]}

Gsell, Pierre-Stephane ^{[2
]}

Brookmeyer, Ron ^{[3
]}

Crawford, Forrest W. ^{[4
]}

Donnelly, Christl A. ^{[5
,7
]}

Ellenberg, Susan S. ^{[10
]}

Fleming, Thomas R. ^{[11
]}

Halloran, M. Elizabeth ^{[11
,12
]}

Horby, Peter ^{[6
]}

Jaki, Thomas ^{[9
]}

Krause, Philip R. ^{[13
]}

Longini, Ira M. ^{[1
]}

Mulangu, Sabue ^{[15
]}

Muyembe-Tamfum, Jean-Jacques ^{[15
]}

Nason, Martha C. ^{[14
]}

Smith, Peter G. ^{[8
]}

Wang, Rui ^{[16
,17
,18
]}

Henao-Restrepo, Ana M. ^{[2
]}

De Gruttola, Victor ^{[18
]}

机构：

[1] Univ Florida, Dept Biostat, Gainesville, FL USA

[2] WHO, Geneva, Switzerland

[3] Univ Calif Los Angeles, Dept Biostat, Los Angeles, CA USA

[4] Yale Univ, Dept Biostat, New Haven, CT USA

[5] Univ Oxford, Dept Stat, Oxford, England

[6] Univ Oxford, Ctr Trop Med & Global Hlth, Oxford, England

[7] Imperial Coll London, Dept Infect Dis Epidemiol, Ctr Global Infect Dis Anal, MRC, London, England

[8] London Sch Hyg & Trop Med, MRC Trop Epidemiol Grp, London, England

[9] Univ Lancaster, Dept Math & Stat, Lancaster, England

[10] Univ Penn, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA

[11] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[12] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, 1124 Columbia St, Seattle, WA 98104 USA

[13] US FDA, Off Vaccines Res & Review, Ctr Biol Evaluat & Res, Silver Spring, MD USA

[14] NIAID, Biostat Res Branch, 9000 Rockville Pike, Bethesda, MD 20892 USA

[15] Inst Natl Rech Biomed, Kinshasa, DEM REP CONGO

[16] Harvard Med Sch, Dept Populat Med, Boston, MA 02115 USA

[17] Harvard Pilgrim Hlth Care Inst, Boston, MA USA

[18] Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2020年 / 382卷 / 14期

基金：

英国医学研究理事会;

关键词：

VACCINE; EBOLA;

D O I：

10.1056/NEJMsb1905390

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

As in the ongoing Covid-19 pandemic, global outbreaks of infectious illnesses often develop quickly and resolve in unpredictable ways. In this report, strategies to develop high-quality evidence to guide the development of new therapies are proposed.

引用

页码：1366 / 1369

页数：4

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