HLA-DRB1 and anti-cyclic citrullinated peptide antibody production in rheumatoid arthritis

被引：11

作者：

Senkpiehl, K

Marget, M

Wedler, M

Jenisch, S

Georgi, J

Kabelitz, D

Steinmann, J

机构：

[1] Univ Kiel, Dept Immunol, D-2300 Kiel, Germany

[2] Ostseeklin Damp, Damp, Germany

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2005年 / 137卷 / 04期

关键词：

rheumatoid arthritis; HLA-DR4; antigen; peptides; HLA-DR1; citrulline; antigen presentation;

D O I：

10.1159/000086463

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 [免疫学];

摘要：

Anti-cyclic citrullinated peptide antibodies (anti-CCP) are a new diagnostic marker for rheumatoid arthritis (RA), which shows a specificity of 97% and a sensitivity of 81% in the second generation assay. About 61% of RA patients express HLA-DRB1*0401. In a cohort of patients with RA we investigated whether the expression of anti-CCP correlates with the carriage of certain genes on the HLA-DRB1 locus. Our data reveal a highly significant association between anti-CCP and HLA-DR4, and a weaker but still significant association with HLA-DR1. HLA-DRB1 *0401 is not a prerequisite for anti-CCP production, but if HLA-DRB1*0401 was present, 90% of our RA patients were anti-CCP positive. Copyright (C) 2005 S. Karger AG, Basel.

引用

页码：315 / 318

页数：4

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