Postural sway and effect of levodopa in early Parkinson's disease

被引：86

作者：

Beuter, Anne ^{[1
]}

Hernandez, Roberto ^{[2
]}

Rigal, Robert ^{[2
]}

Modolo, Julien ^{[1
]}

Blanchet, Pierre J. ^{[3
]}

机构：

[1] Univ Victor Seagalen Bordeaux 2, Inst cognit, F-33060 Bordeaux, France

[2] Univ Quebec, Dept Kinanthropol, Montreal, PQ, Canada

[3] Univ Montreal, Fac Med Dentaire, Dept Stomatol, Montreal, PQ, Canada

来源：

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES | 2008年 / 35卷 / 01期

关键词：

D O I：

10.1017/S0317167100007575

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To characterize postural stability control and levodopa responsiveness in early Parkinson's disease (PD). Methods: Postural sway was studied during quiet stance in ten patients within six years of PD onset, both before (OFF) and after (ON) regular oral levodopa dosing. Postural sway was recorded using a force platform during 30 sec with eyes open, and six dependent variables were examined. Results: Mild baseline subclinical changes in postural sway were recorded in our patients. Clear benefit was observed in five out of six characteristics (mean sway, transversal sway, sagittal sway, sway intensity, and sway area) in the ON condition. Conclusion: Postural control mechanisms are affected early in PD and modulated by dopamine.

引用

页码：65 / 68

页数：4

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