Uptake of 18F-FLT and 18F-FDG in primary head and neck cancer correlates with survival

被引：40

作者：

Lineker, A. ^{[2
]}

Kermer, C. ^{[2
]}

Sulzbacher, I. ^{[4
]}

Angelberger, P. ^{[5
]}

Kletter, K. ^{[3
]}

Dudczak, R. ^{[3
]}

Ewers, R. ^{[2
]}

Becherer, A. ^{[1
,3
]}

机构：

[1] LKH Feldkirch, Dept Nucl Med, A-6800 Feldkirch, Austria

[2] Univ Vienna, Dept Craniomaxillofacial Surg, A-1010 Vienna, Austria

[3] Univ Vienna, Dept Nucl Med, A-1010 Vienna, Austria

[4] Univ Vienna, Dept Pathol, A-1010 Vienna, Austria

[5] ARC Seibersdorf Res GmbH, Seibersdorf, Austria

来源：

NUKLEARMEDIZIN-NUCLEAR MEDICINE | 2008年 / 47卷 / 02期

关键词：

head-and-neck cancer; fluorothymidine; fluorodeoxyglucose; PET; prognosis; survival;

D O I：

10.3413/nukmed-0092

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The aim of the study was to determine the practicability of F-18-FLT in tumours of the head and neck area in terms of visualization, a possible correlation between FIT uptake and proliferation fraction as determined by Ki-67 immunostaining, and if tumoural FIT-uptake has a prognostic meaning,as determined by a correlation to patient survival time. Results were compared to F-18-FDG. Patients, methods: 20 patients with previously untreated lesions of the head and neck area, which were clinically highly suspicious to be malignant, underwent PET scans with 18F-FLT and F-18-FDG, a CT of the head and neck area, and a biopsy. Tumour tracer uptake was determined by standardized uptake value (SUV) normalized to body weight and /non-tumor ratios (T/N). F-18-FDG and F-18-FLT uptake were compared with histopathologic and immunohistochemical results. Results: 19 patients had malignant tumours, one patient had a benign cystodenoma (so called Worthin's tumour) of the parotid gland. One negative lesion turned out to be a malignant T1 stage squamous cell carcinoma in both PET scans, the Warthin's tumour was false positive with F-18-FDG but showed only faint uptake with F-18-FIT, resulting in a sensitivity of 95 % for both tracers. Of all lesions, maximum SUVs of F-18-FLT ranged from 1.53 to 11.70 (mean +/- SD 5.81 +/- 2.28) those of FDG from 2.63 to 16.50 (mean +/- SD 8.91 +/- 3.58), p < 0.001. F-18-FLT-T/N ranged from 0.94 to 5.85 (mean +/- SD, 3.18 +/- 1.21), F-18-FDG-T/N was from 0.92 to 7.50 (mean +/- SD, 3.6 +/- 1.74), n.s. The mean survival time was 18 months in a maximum follow up time of 36 months. A significant correlation between both PET tracers and survival was detected, but no correlation between the amount of Ki-67 positive cells and FIT. Conclusion: In head and neck cancer in the primary setting 18F-FLT does not provide additional visual information in comparison to F-18-FDG.F-18-FLT uptake is inversely correlated with patient survival, as well as F-18-FDG.

引用

页码：80 / 85

页数：6

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