Antibiotic resistance is ancient

被引：1801

作者：

D'Costa, Vanessa M. ^{[1
,2
]}

King, Christine E. ^{[3
,4
]}

Kalan, Lindsay ^{[1
,2
]}

Morar, Mariya ^{[1
,2
]}

Sung, Wilson W. L. ^{[4
]}

Schwarz, Carsten ^{[3
]}

Froese, Duane ^{[5
]}

Zazula, Grant ^{[6
]}

Calmels, Fabrice ^{[5
]}

Debruyne, Regis ^{[7
]}

Golding, G. Brian ^{[4
]}

Poinar, Hendrik N. ^{[1
,3
,4
]}

Wright, Gerard D. ^{[1
,2
]}

机构：

[1] McMaster Univ, Michael G DeGroote Inst Infect Dis Res, Hamilton, ON L8N 3Z5, Canada

[2] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON L8N 3Z5, Canada

[3] McMaster Univ, Dept Anthropol, McMaster Ancient DNA Ctr, Hamilton, ON L8S 4L9, Canada

[4] McMaster Univ, Dept Biol, Hamilton, ON L8S 4K1, Canada

[5] Univ Alberta, Dept Earth & Atmospher Sci, Edmonton, AB T6G 2E3, Canada

[6] Yukon Govt, Dept Tourism & Culture, Yukon Palaeontol Program, Whitehorse, YT Y1A 2C6, Canada

[7] Museum Natl Hist Nat, UMR Ecoanthropol 7206, F-75231 Paris 05, France

来源：

NATURE | 2011年 / 477卷 / 7365期

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

YUKON-TERRITORY; PERMAFROST; RESISTOME; SEDIMENTS; BACTERIA; MAMMALS; ICE;

D O I：

10.1038/nature10388

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The discovery of antibiotics more than 70 years ago initiated a period of drug innovation and implementation in human and animal health and agriculture. These discoveries were tempered in all cases by the emergence of resistant microbes(1,2). This history has been interpreted to mean that antibiotic resistance in pathogenic bacteria is a modern phenomenon; this view is reinforced by the fact that collections of microbes that predate the antibiotic era are highly susceptible to antibiotics(3). Here we report targeted metagenomic analyses of rigorously authenticated ancient DNA from 30,000-year-old Beringian permafrost sediments and the identification of a highly diverse collection of genes encoding resistance to beta-lactam, tetracycline and glycopeptide antibiotics. Structure and function studies on the complete vancomycin resistance element VanA confirmed its similarity to modern variants. These results show conclusively that antibiotic resistance is a natural phenomenon that predates the modern selective pressure of clinical antibiotic use.

引用

页码：457 / 461

页数：5

共 21 条

[1]

Baltz R.H., 2005, SIM News, V55, P186

[2] Low temperature (LT) combustion of sediments does not necessarily provide accurate radiocarbon ages for site chronology [J].