From genes to drugs: targeted strategies for melanoma

被引：284

作者：

Flaherty, Keith T. ^{[1
]}

Hodi, F. Stephen ^{[2
]}

Fisher, David E. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA

[2] Dana Farber Canc Inst, Boston, MA 02115 USA

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 05期

关键词：

COLONY-STIMULATING FACTOR; CYTOLYTIC T-LYMPHOCYTES; PHASE-II TRIAL; FIBROBLAST-GROWTH-FACTOR; TUMOR-INFILTRATING LYMPHOCYTES; CELL-CYCLE ARREST; MHC CLASS-I; DENDRITIC CELLS; METASTATIC MELANOMA; MALIGNANT-MELANOMA;

D O I：

10.1038/nrc3218

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The past decade has revealed that melanoma is comprised of multiple subclasses that can be categorized on the basis of key features, including the clinical stage of disease, the oncogenic molecular 'drivers', the anatomical location or the behaviour of the primary lesion and the expression of specific biomarkers. Although exercises in subclassification are not new in oncology, progress in this area has produced both conceptual and clinical breakthroughs, which, for melanoma, are unprecedented in the modern history of the disease. This Review focuses on these recent striking advances in the strategy of molecularly targeted approaches to the therapy of melanoma in humans.

引用

页码：349 / 361

页数：13

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