Rethinking Communication in the Immune System: The Quorum Sensing Concept

被引：31

作者：

Antonioli, Luca ^{[1
,2
]}

Blandizzi, Corrado ^{[1
]}

Pacher, Pal ^{[3
]}

Guilliams, Martin ^{[4
,5
]}

Hasko, Gyorgy ^{[2
]}

机构：

[1] Univ Pisa, Dept Clin & Expt Med, I-56126 Pisa, Italy

[2] Columbia Univ, Dept Anesthesiol, New York, NY 10032 USA

[3] NIAAA, NIH, Lab Cardiovasc Physiol & Tissue Injury, Bethesda, MD 20892 USA

[4] VIB, Ctr Inflammat Res, Lab Myeloid Cell Ontogeny & Funct Specializat, Technol Pk 927, Ghent, Belgium

[5] Univ Ghent, Dept Biomed Mol Biol, Ghent, Belgium

来源：

TRENDS IN IMMUNOLOGY | 2019年 / 40卷 / 02期

基金：

美国国家卫生研究院;

关键词：

REGULATORY T-CELLS; DENDRITIC CELLS; MACROPHAGES; REVEALS; IL-2; PROLIFERATION; HOMEOSTASIS;

D O I：

10.1016/j.it.2018.12.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Quorum sensing was first described as the communication process bacteria employ to coordinate changes in gene expression and therefore, their collective behavior in response to population density. Emerging new evidence suggests that quorum sensing can also contribute to the regulation of immune cell responses. Quorum sensing might be achieved by the ability of immune cells to perceive the density of their own populations or those of other cells in their environment; responses to alterations in cell density might then be coordinated via changes in gene expression and protein signaling. Quorum sensing mechanisms can regulate T and B cell as well as macrophage function. We posit that perturbations in quorum sensing may undermine the balance between diverse immune cell populations and predispose the host to immune abnormalities.

引用

页码：88 / 97

页数：10

共 54 条

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