Brain functional changes in facial expression recognition in patients with major depressive disorder before and after antidepressant treatment A functional magnetic resonance imaging study

被引：22

作者：

Jiang, Wenyan ^{[2
]}

Yin, Zhongmin ^{[3
]}

Pang, Yixin ^{[2
]}

Wu, Feng ^{[2
]}

Kong, Lingtao ^{[2
]}

Xu, Ke ^{[1
]}

机构：

[1] China Med Univ, Affiliated Hosp 1, Dept Radiol, Shenyang 110001, Liaoning Provin, Peoples R China

[2] China Med Univ, Affiliated Hosp 1, Dept Psychiat, Shenyang 110001, Liaoning Provin, Peoples R China

[3] PLA 463 Hosp, Dept Neurosurg, Shenyang 110042, Liaoning Provin, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2012年 / 7卷 / 15期

基金：

中国国家自然科学基金;

关键词：

major depressive disorder; functional magnetic resonance imaging; facial expression recognition; antidepressant; neural regeneration; ANTERIOR CINGULATE CORTEX; TREATMENT-RESPONSE; PREFRONTAL CORTEX; NEURAL RESPONSE; AMYGDALA; STATE; FACES; SAD; CONNECTIVITY; 1ST-EPISODE;

D O I：

10.3969/j.issn.1673-5374.2012.15.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Functional magnetic resonance imaging was used during emotion recognition to identify changes in functional brain activation in 21 first-episode, treatment-naive major depressive disorder patients before and after antidepressant treatment. Following escitalopram oxalate treatment, patients exhibited decreased activation in bilateral precentral gyrus, bilateral middle frontal gyrus, left middle temporal gyrus, bilateral postcentral gyrus, left cingulate and right parahippocampal gyrus, and increased activation in right superior frontal gyrus, bilateral superior parietal lobule and left occipital gyrus during sad facial expression recognition. After antidepressant treatment, patients also exhibited decreased activation in the bilateral middle frontal gyrus, bilateral cingulate and right parahippocampal gyrus, and increased activation in the right inferior frontal gyrus, left fusiform gyrus and right precuneus during happy facial expression recognition. Our experimental findings indicate that the limbic-cortical network might be a key target region for antidepressant treatment in major depressive disorder.

引用

页码：1151 / 1157

页数：7

共 38 条

[1]

The Subgenual Anterior Cingulate Cortex in Mood Disorders [J].