Pharmacological relapse prevention in alcohol dependence: From animal models to clinical trials

被引：26

作者：

Boening, JAL

Lesch, OM

Spanagel, R

Wolffgramm, J

Narita, M

Sinclair, D

Mason, BJ

Wiesbeck, GA

机构：

[1] Univ Wurzburg, Psychiat Clin, Addict Res Program, D-97080 Wurzburg, Germany

[2] Univ Wurzburg, Dept Psychiat, D-97080 Wurzburg, Germany

[3] Univ Vienna, Dept Psychiat, A-1010 Vienna, Austria

[4] Heidelberg Univ, Cent Inst Mental Hlth, D-6800 Mannheim, Germany

[5] Univ Tubingen, Dept Psychiat, D-72074 Tubingen, Germany

[6] Hoshi Univ, Sch Pharm, Dept Tosicol, Tokyo 142, Japan

[7] Natl Publ Hlth Inst, Dept Mental Hlth & Alcohol Res, Helsinki, Finland

[8] Univ Miami, Div Substance Abuse, Dept Psychiat & Behav Sci, Coral Gables, FL 33124 USA

来源：

ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH | 2001年 / 25卷 / 05期

关键词：

alcohol addiction; NMDA; protein kinase C; naltrexone; animal models;

D O I：

10.1111/j.1530-0277.2001.tb02386.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Jobst August-Ludwig Boening and Otto Michel Lesch. The presentations were (1) Pharmacological validation of a new animal model of alcoholism, by Rainer Spanagel; (2) Persisting loss of control as main criterion for alcohol addiction in rats and mice, by Jochen Wolffgramm; (3) Role of NMDA receptor subunits associated with protein kinase C in the prevention of alcohol dependence, by Minoru Narita; (4) Long-term follow up of continued naltrexone treatment, by David Sinclair; (5) Pharmacological treatment trials with dopaminergic and serotonergic substances: Myths: or facts? by Gerhard A. Wiesbeck; and (6) Methodology and behavioral therapy of the U.S. acamprosate study, by Barbara J. Mason.

引用

页码：127S / 131S

页数：5

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