Subregion-specific dendritic spine abnormalities in the hippocampus of Fmr1 KO mice

被引：42

作者：

Levenga, Josien ^{[1
]}

de Vrij, Femke M. S. ^{[1
]}

Buijsen, Ronald A. M. ^{[1
]}

Li, Tracy ^{[1
]}

Nieuwenhuizen, Ingeborg M. ^{[1
]}

Pop, Andreea ^{[1
]}

Oostra, Ben A. ^{[1
]}

Willemsen, Rob ^{[1
]}

机构：

[1] Erasmus MC, CBG Dept Clin Genet, NL-3015 GE Rotterdam, Netherlands

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2011年 / 95卷 / 04期

关键词：

Fragile X syndrome; Spines; Hippocampus; FMR1; FMRP; X MENTAL-RETARDATION; METABOTROPIC GLUTAMATE RECEPTORS; KNOCKOUT MICE; MOUSE MODEL; PROTEIN; NEURONS; CORTEX; CA3; TRANSLATION; DISORDERS;

D O I：

10.1016/j.nlm.2011.02.009

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Fragile X syndrome (FXS) is the most common inherited form of mental retardation and is caused by the lack of fragile X mental retardation protein (FMRP). In the brain, spine abnormalities have been reported in both patients with FXS and Fmr1 knockout mice. This altered spine morphology has been linked to disturbed synaptic transmission related to altered signaling in the excitatory metabotropic glutamate receptor 5 (mGluR5) pathway. We investigated hippocampal protrusion morphology in adult Fmr1 knockout mice. Our results show a hippocampal CA1-specific altered protrusion phenotype, which was absent in the CA3 region of the hippocampus. This suggests a subregion-specific function of FMRP in synaptic plasticity in the brain. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：467 / 472

页数：6

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