Improved power of sib-pair linkage analysis using measures of complex trait dynamics

被引：2

作者：

Moore, JH ^{[1
]}

机构：

[1] Vanderbilt Univ, Sch Med, Dept Physiol & Mol Biophys, Program Human Genet, Nashville, TN 37232 USA

来源：

HUMAN HEREDITY | 2001年 / 52卷 / 02期

关键词：

linkage analysis; power; complex traits; epistasis; nonlinear dynamics;

D O I：

10.1159/000053363

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The influence of epistasis on a quantitative trait can reduce the power of linkage analysis to identify the underlying loci. In the present study, we simulated a complex trait derived from a dynamic one-locus gene expression system with epistasis arising from feedback regulation and tested the power of sib-pair linkage analysis methods for detecting the underlying quantitative trait locus (QTL). Using this simple genetic architecture, we demonstrate that the power of sib-pair linkage analysis can be greatly improved if measures of complex trait dynamics are considered. Copyright (C) 2001 S. Karger AG, Basel.

引用

页码：113 / 115

页数：3

共 13 条

[1]

[Anonymous], 1995, ADAPTATION BUILDS CO

[2]

Eaves L J, 1999, Twin Res, V2, P43, DOI 10.1375/twin.2.1.43

[3]

FULKER DW, 1994, AM J HUM GENET, V54, P1092

[4] RENAL BLOOD-FLOW REGULATION AND ARTERIAL-PRESSURE FLUCTUATIONS - A CASE-STUDY IN NONLINEAR DYNAMICS [J].