Goblet cells of the conjunctiva: A review of recent findings

被引：182

作者：

Gipson, Ilene K. ^{[1
]}

机构：

[1] Harvard Med Sch, Dept Ophthalmol, Schepens Eye Res Inst, 20 Staniford St, Boston, MA 02114 USA

来源：

PROGRESS IN RETINAL AND EYE RESEARCH | 2016年 / 54卷

关键词：

Goblet cell; Goblet cell differentiation; Conjunctival epithelium; Ocular surface; SPDEF; Dry eye; OCULAR SURFACE EPITHELIUM; VITAMIN-A-DEFICIENCY; DRY EYE; STEM-CELLS; HUMAN CORNEAL; MUCIN GENES; IMPRESSION CYTOLOGY; RABBIT CONJUNCTIVAL; SMALL-INTESTINE; CLONAL ANALYSIS;

D O I：

10.1016/j.preteyeres.2016.04.005

中图分类号：

R77 [眼科学];

学科分类号：

100212 [眼科学];

摘要：

Goblet cells within the conjunctival epithelium are specialized cells that secrete mucins onto the surface of the eye. Recent research has demonstrated new characteristics of the cells, including factors influencing their differentiation, their gene products and their functions at the ocular surface. The following review summarizes the newly discovered aspects of the role of Spdef, a member of the Ets transcription factor family in conjunctival goblet cell differentiation, the newly discovered goblet cell products including claudin2, the Wnt inhibitor Frzb, and the transmembrane mucin Muc16. The current concepts of conjunctival goblet cell function, including debris removal and immune surveillance are reviewed, as are changes in the goblet cell population in ocular surface diseases. Major remaining questions regarding conjunctival cell biology are discussed. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：49 / 63

页数：15

共 93 条

[1]

MUC16 mucin is expressed by the human ocular surface epithelia and carries the H185 carbohydrate epitope [J].