Strain dependence of airway hyperresponsiveness reflects differences in eosinophil localization in the lung

被引:112
作者
Takeda, K
Haczku, A
Lee, JJ
Irvin, CG
Gelfand, EW
机构
[1] Natl Jewish Med & Res Ctr, Dept Pediat, Div Cell Biol, Denver, CO 80206 USA
[2] Natl Jewish Med & Res Ctr, Dept Med, Denver, CO 80206 USA
[3] Mayo Clin Scottsdale, Scottsdale, AZ 85259 USA
关键词
D O I
10.1152/ajplung.2001.281.2.L394
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Different strains of mice exhibit different degrees of airway hyperresponsiveness after sensitization to and airway challenge with ovalbumin. Antibody responses in BALB/c mice far exceeded those in C57BL/6 mice; in contrast, although responsiveness to methacholine was much higher in the BALB/c mice, the number of eosinophils in the bronchoalveolar lavage fluid was higher in C57BL/6 animals. Sensitized and challenged BALB/c mice developed increases in lung resistance and decreases in dynamic compliance after methacholine or 5-hydroxytryptamine inhalation. C57BL/6 mice only exhibited significant levels of responsiveness when dynamic compliance was monitored in response to inhaled 5-hydroxytryptamine. Eosinophils accumulated in the peribronchial and peripheral lung tissue in BALB/c mice but were distributed diffusely in the peripheral lung tissue of C57BL/6 mice. Thus, in addition to differences in antibody responses and cholinergic agonist reactivity, differences in the responses of large and small airways may reflect the selective distribution of eosinophils in lung tissue.
引用
收藏
页码:L394 / L402
页数:9
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