Calcium ionophore A 23187 induces apoptotic cell death in rat thymocytes

被引：16

作者：

Azmi, S ^{[1
]}

Dhawan, D ^{[1
]}

Singh, N ^{[1
]}

机构：

[1] ALL INDIA INST MED SCI,DEPT BIOCHEM,NEW DELHI 110029,INDIA

来源：

CANCER LETTERS | 1996年 / 107卷 / 01期

关键词：

calcium ionophore A 23187; apoptosis; poly ADPR polymerase; thymocytes; genes;

D O I：

10.1016/0304-3835(96)04349-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Apoptotic cell death was induced in rat thymocytes on exposure to calcium ionophore A 23187 (100 mu m) for 24 h as observed from morphological changes and DNA fragmentation into oligonucleosomal ladder. The cell death was independent of de novo syntheses of protein. However, the involvement of c-Myc, c-Jun, poly ADPR polymerase and antioxidant enzymes CuZn SOD and catalase was observed.

引用

页码：97 / 103

页数：7

共 22 条

[1]

AKIHIRO K, 1995, FEBS LETT, V36, P264

[2]

ANGULAR D, 1991, J IMMUNOL, V146, P1072

[3]

ARENDS MJ, 1990, AM J PATHOL, V136, P593

[4]

AUSEBEL FM, 1987, CURRENT PROTOCOLS MO

[5]

BARR PJ, 1994, BIO-TECHNOL, V12, P487, DOI 10.1038/nbt0594-487

[6] CHARACTERIZATION AND COMPARISON OF POLY(ADENOSINE DIPHOSPHORIBOSE) SYNTHESIS AND DNA-SYNTHESIS IN NUCLEOTIDE-PERMEABLE CELLS [J].

BERGER, NA ;

WEBER, G ;

KAICHI, AS .

BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 519 (01) :87-104

[7] REGIONAL DISTRIBUTION OF CATALASE IN THE ADULT-RAT BRAIN [J].

BRANNAN, TS ;

MAKER, HS ;

RAES, IP .

JOURNAL OF NEUROCHEMISTRY, 1981, 36 (01) :307-309

[8]

COHEN JJ, 1993, IMMUNOL TODAY, V14, P126, DOI 10.1016/0167-5699(93)90214-6

[9]

COHEN JJ, 1984, J IMMUNOL, V132, P38

[10] APOPTOSIS INDUCED BY C-MYC OVEREXPRESSION IS DEPENDENT ON GROWTH-CONDITIONS [J].

GIBSON, AW ;

CHENG, T ;

JOHNSTON, RN .

EXPERIMENTAL CELL RESEARCH, 1995, 218 (01) :351-358

← 1 2 3 →