A neuropeptide courier for δ-opioid receptors?

被引：8

作者：

Julius, D ^{[1
]}

Basbaum, AI

机构：

[1] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, WM Keck Fdn Ctr Integrat Neurosci, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

来源：

CELL | 2005年 / 122卷 / 04期

关键词：

D O I：

10.1016/j.cell.2005.08.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The delta-opioid receptor and the precursor protein of a neuropeptide, substance P, are colocalized in the large dense-core vesicles of pain-sensing neurons. In this issue of Cell, Guan et al. (2005) report that trafficking of the delta-opioid receptor to these vesicles depends on its physical interaction with the substance P domain of its precursor polyprotein (protachykinin). Moreover, in mice lacking this precursor, the contribution of the delta-opioid receptor to pain processing is dramatically altered. These observations suggest a new role for peptide precursors as sorting signals in vesicular transport.

引用

页码：496 / 498

页数：3

共 10 条

[1]

Acosta CG, 1999, J NEUROSCI, V19, P8337

[2] Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion [J].

Bao, L ;

Jin, SX ;

Zhang, C ;

Wang, LH ;

Xu, ZZ ;

Zhang, FX ;

Wang, LC ;

Ning, FS ;

Cai, HJ ;

Guan, JS ;

Xiao, HS ;

Xu, ZQD ;

He, C ;

Hökfelt, T ;

Zhou, Z ;

Zhang, X .

NEURON, 2003, 37 (01) :121-133

[3] Pain [J].

Basbaum, AI ;

Woolf, CJ .

CURRENT BIOLOGY, 1999, 9 (12) :R429-R431

[4] Prolonged morphine treatment targets δ opioid receptors to neuronal plasma membranes and enhances δ-mediated antinociception [J].

Cahill, CM ;

Morinville, A ;

Lee, MC ;

Vincent, JP ;

Collier, B ;

Beaudet, A .

JOURNAL OF NEUROSCIENCE, 2001, 21 (19) :7598-7607

[5] Primary afferent tachykinins are required to experience moderate to intense pain [J].

Cao, YQ ;

Mantyh, PW ;

Carlson, EJ ;

Gillespie, AM ;

Epstein, CJH ;

Basbaum, AI .

NATURE, 1998, 392 (6674) :390-394

[6] Altered nociception, analgesia and aggression in mice lacking the receptor for substance P [J].

De Felipe, C ;

Herrero, JF ;

O'Brien, JA ;

Palmer, JA ;

Doyle, CA ;

Smith, AJH ;

Laird, JMA ;

Belmonte, C ;

Cervero, F ;

Hunt, SP .

NATURE, 1998, 392 (6674) :394-397

[7] Interaction with vesicle luminal protachykinin regulates surface expression of δ-opioid receptors and opioid analgesia [J].

Guan, JS ;

Xu, ZZ ;

Gao, H ;

He, SQ ;

Ma, GQ ;

Sun, T ;

Wang, LH ;

Zhang, ZN ;

Lena, I ;

Kitchen, I ;

Elde, R ;

Zimmer, A ;

He, C ;

Pei, G ;

Bao, L ;

Zhang, X .

CELL, 2005, 122 (04) :619-631

[8] PATHWAYS OF PROTEIN SECRETION IN EUKARYOTES [J].

KELLY, RB .

SCIENCE, 1985, 230 (4721) :25-32

[9] NUCLEOTIDE-SEQUENCES OF CLONED CDNAS FOR 2 TYPES OF BOVINE BRAIN SUBSTANCE-P PRECURSOR [J].

NAWA, H ;

HIROSE, T ;

TAKASHIMA, H ;

INAYAMA, S ;

NAKANISHI, S .

NATURE, 1983, 306 (5938) :32-36

[10]

Potrebic S, 2003, J NEUROSCI, V23, P10988

← 1 →