The continuing challenge of hepatic cancer in Asia

被引:201
作者
Lai, ECH [1 ]
Lau, WY [1 ]
机构
[1] Prince Wales Hosp, Dept Surg, Hong Kong, Hong Kong, Peoples R China
来源
SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND | 2005年 / 3卷 / 03期
关键词
hepatocellular carcinoma; hepatectomy; liver transplantation; non-surgical treatment; hepatitis;
D O I
10.1016/S1479-666X(05)80043-5
中图分类号
R61 [外科手术学];
学科分类号
摘要
Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world. The number of new cases is estimated to be 564,000 per year. About 80% of all cases are found in Asia. The goal of HCC management is "cancer control" - a reduction in its incidence and mortality as well as an improvement in the quality of life of patients with HCC and their family. Overall, 80% of HCC can be attributed to chronic hepatitis B and C infection. Prevention of infection with hepatitis B and C virus is the key strategy to reduce the incidence of HCC in Asia. Liver resection and liver transplantation remain the options that give the best chance of a cure. In the past two decades, operative mortality and surgical outcome of liver resection and liver transplantation for HCC have improved. Progress also has been made in multi-modality therapy which can increase the chance of survival and improve the quality of life for patients with advanced HCC. Many challenges are still present in Asia, such as the high prevalence of chronic hepatitis, the low resection rate of HCC, the high postoperative recurrence and the severe shortage of cadaveric organ donor. This article aims to discuss the development and challenges in the prevention and management of HCC in Asia.
引用
收藏
页码:210 / 215
页数:6
相关论文
共 53 条
  • [1] Extended hepatectomy in patients with hepatobiliary malignancies with and without preoperative portal vein embolization
    Abdalla, EK
    Barnett, CC
    Doherty, D
    Curley, SA
    Vauthey, JN
    [J]. ARCHIVES OF SURGERY, 2002, 137 (06) : 675 - 680
  • [2] Adam R, 2003, ANN SURG, V238, P508, DOI 10.1097/01.sla.0000090449.87109.44
  • [3] Resection prior to liver transplantation for hepatocellular carcinoma
    Beighiti, J
    Cortes, A
    Abdalla, EK
    Régimbeau, JM
    Prakash, K
    Durand, F
    Sommacale, D
    Dondero, F
    Lesurtel, M
    Sauvanet, A
    Farges, O
    Kianmanesh, R
    [J]. ANNALS OF SURGERY, 2003, 238 (06) : 885 - 892
  • [4] Primary liver cancer:: Worldwide incidence and trends
    Bosch, FX
    Ribes, J
    Díaz, M
    Cléries, R
    [J]. GASTROENTEROLOGY, 2004, 127 (05) : S5 - S16
  • [5] Adjuvant intra-arterial injection of iodine-131-labeled lipiodol after resection of hepatocellular carcinoma
    Boucher, E
    Corbinais, S
    Rolland, Y
    Bourguet, P
    Guyader, D
    Boudjema, K
    Meunier, B
    Raoul, JL
    [J]. HEPATOLOGY, 2003, 38 (05) : 1237 - 1241
  • [6] CHAN ES, 2000, COCHRANE DB SYST REV, V2
  • [7] Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children
    Chang, MH
    Chen, CJ
    Lai, MS
    Hsu, HM
    Wu, TC
    Kong, MS
    Liang, DC
    Shau, WY
    Chen, DS
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (26) : 1855 - 1859
  • [8] Living-donor liver transplantation: 12 years of experience in Asia
    Chen, CL
    Fan, ST
    Lee, SG
    Makuuchi, M
    Tanaka, K
    [J]. TRANSPLANTATION, 2003, 75 (03) : S6 - S11
  • [9] Chinese experience with hepatectomy for huge hepatocellular carcinoma
    Chen, XP
    Qiu, FZ
    Wu, ZD
    Zhang, BX
    [J]. BRITISH JOURNAL OF SURGERY, 2004, 91 (03) : 322 - 326
  • [10] Multimodality tumor control and living donor transplantation for unresectable hepatocellular carcinoma
    Chui, AKK
    Rao, ARN
    Island, ER
    Chan, HLY
    Leung, TWT
    Lau, WY
    [J]. TRANSPLANTATION PROCEEDINGS, 2004, 36 (08) : 2287 - 2288