A rhodium-catalyzed route for oxidative coupling and cyclization of 2-aminobenzyl alcohol with ketones leading to quinolines

被引：49

作者：

Cho, CS ^{[1
]}

Seok, HJ

Shim, SC

机构：

[1] Kyungpook Natl Univ, Ind Technol Res Inst, Taegu 702701, South Korea

[2] Kyungpook Natl Univ, Dept Appl Chem, Coll Engn, Taegu 702701, South Korea

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2005年 / 42卷 / 06期

关键词：

D O I：

10.1002/jhet.5570420630

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Aminobenzyl alcohol undergoes oxidative cyclization with aryl(alkyl), alkyl(alkyl) and cyclic ketones in dioxane at 80 degrees in the presence of a catalytic amount of RhCI(PPh3)(3) along with KOH to afford the corresponding quinolines in good yields. The catalytic pathway seems to be proceeded via a sequence involving initial oxidation of 2-aminobenzyl alcohol to 2-aminobenzaldehyde by a rhodium catalyst, cross aldol reaction between 2-aminobenzaldehyde and ketones, and cyclodehydration.

引用

页码：1219 / 1222

页数：4

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