Inflammatory disease - Assault on the guardian

被引：17

作者：

Ransohoff, Richard M. ^{[1
]}

机构：

[1] Cleveland Clin Fdn, Neuroinflammat Res Ctr, Dept Neurosci, Lerner Res Inst, Cleveland, OH 44195 USA

来源：

NATURE | 2007年 / 448卷 / 7152期

关键词：

D O I：

10.1038/448421a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In multiple sclerosis, the immune system attacks 'self' tissues. Ten years after the discovery of one target of this autoimmunity, work with mice identifies it as a guardian protein produced in response to inflammation.

引用

页码：421 / 422

页数：2

共 13 条

[1]

Alge CS, 2002, INVEST OPHTH VIS SCI, V43, P3575

[2] Expression of alpha B-crystallin in glia cells during lesional development in multiple sclerosis [J].

Bajramovic, JJ ;

Lassmann, H ;

vanNoort, JM .

JOURNAL OF NEUROIMMUNOLOGY, 1997, 78 (1-2) :143-151

[3] Presentation of αB-crystallin to T cells in active multiple sclerosis lesions:: An early event following inflammatory demyelination [J].

Bajramovic, JJ ;

Plomp, AC ;

van der Goes, A ;

Koevoets, C ;

Newcombe, J ;

Cuzner, ML ;

van Noort, JM .

JOURNAL OF IMMUNOLOGY, 2000, 164 (08) :4359-4366

[4] A pathogenic role for myelin-specific CD8+ T cells in a model for multiple sclerosis [J].

Huseby, ES ;

Liggitt, D ;

Brabb, T ;

Schnabel, B ;

Öhlén, C ;

Goverman, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (05) :669-676

[5]

Ousman SS, 2007, NATURE, V448, P474, DOI 10.1038/nature05935

[6] A novel rationale for inhibition of gelatinase B in multiple sclerosis:: MMP-9 destroys αB-crystallin and generates a promiscuous T cell epitope [J].

Starckx, S ;

Van den Steen, PE ;

Verbeek, R ;

van Noort, JM ;

Opdenakker, G .

JOURNAL OF NEUROIMMUNOLOGY, 2003, 141 (1-2) :47-57

[7] CRYAB promoter polymorphisms:: Influence on multiple sclerosis susceptibility and clinical presentation [J].

Stoevring, Birgitte ;

Frederiksen, Jette L. ;

Christiansen, Michael .

CLINICA CHIMICA ACTA, 2007, 375 (1-2) :57-62

[8] Autoantibodies against alpha B-crystallin, a candidate autoantigen in multiple sclerosis, are part of a normal human immune repertoire [J].

van Noort, JM ;

Verbeek, R ;

Meilof, JF ;

Polman, CH ;

Amor, S .

MULTIPLE SCLEROSIS JOURNAL, 2006, 12 (03) :287-293

[9]

van Sechel AC, 1999, J IMMUNOL, V162, P129

[10] T- and B-cell nonresponsiveness to self-αB-crystallin in SJL mice prevents the induction of experimental allergic encephalomyelitis [J].

van Stipdonk, MJB ;

Willems, AA ;

Verbeek, R ;

Boog, CJP ;

van Noort, JM .

CELLULAR IMMUNOLOGY, 2000, 204 (02) :128-134

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