Clearance of amyloid-β by circulating lipoprotein receptors

被引：360

作者：

Sagare, Abhay

Deane, Rashid

Bell, Robert D.

Johnson, Bradley

Hamm, Katie

Pendu, Ronan

Marky, Andrew

Lenting, Peter J.

Wu, Zhenhua

Zarcone, Troy

Goate, Alison

Mayo, Kevin

Perlmutter, David

Coma, Mireia

Zhong, Zhihui

Zlokovic, Berislav V. ^{[1
]}

机构：

[1] Univ Rochester, Sch Med, Dept Neurosurg, Frank P Smith Lab Neurosci & Neurosurg Res, Rochester, NY 14642 USA

[2] Univ Med Ctr Utrecht, Dept Hematol, Lab Thrombosis & Haemostasis, NL-3584 CX Utrecht, Netherlands

[3] Univ Rochester, Sch Med, Dept Environm Med, Neurobehav Facil Lab, Rochester, NY USA

[4] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA

来源：

NATURE MEDICINE | 2007年 / 13卷 / 09期

关键词：

D O I：

10.1038/nm1635

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Low-density lipoprotein receptor-related protein-1 (LRP) on brain capillaries clears amyloid beta-peptide (Ab) from brain. Here, we show that soluble circulating LRP (sLRP) provides key endogenous peripheral 'sink' activity for Ab in humans. Recombinant LRP cluster IV (LRP-IV) bound Ab in plasma in mice and Alzheimer's disease-affected humans with compromised sLRP-mediated Ab binding, and reduced Ab-related pathology and dysfunction in a mouse model of Alzheimer disease, suggesting that LRP-IV can effectively replace native sLRP and clear Ab.

引用

页码：1029 / 1031

页数：3

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