Effect of PG-SPI and PG-KII, two novel and natural tachykinins, on salivary secretion in the rat

被引:9
作者
Broccardo, M
Improta, G
Brandoni, A
Tabacco, A
机构
[1] Institute of Pharmacology, University La Sapienza, 00185, Rome
关键词
tachykinins; PG-SPI; PG-KII; salivary secretion;
D O I
10.1016/0196-9781(96)00052-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In an in vivo study of salivation in rats, the scialogogic effects of two natural and amphibian tachykinins, PG-SPI and PG-KII, which activate distinct tachykinin receptors, were compared with those of the tachykinins substance P, neurokinin A and B, and kassinin. The rank order of potencies of these peptides injected intravenously on salivation was: PG-SPI = SP greater than or equal to PG-KII = KASS > NKA >> NKB. Atropine (1 mg/kg, IV) had no effect on PG-SPI-, SP-, and NKA-induced salivation, but reduced that stimulated by PG-KII and KASS. We conclude that PG-SPI and PG-KII increase salivary secretion through different mechanisms and that rat salivary glands contain PG-SPI- and PG-KII-sensitive receptors.
引用
收藏
页码:729 / 731
页数:3
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