Sequential occurrence of non-small cell and small cell lung cancer with the same EGFR mutation

被引：116

作者：

Morinaga, Ryotaro ^{[1
]}

Okamoto, Isamu ^{[1
]}

Furuta, Kazuyuki ^{[2
]}

Kawano, Yukiko ^{[2
]}

Sekijima, Masaru ^{[2
]}

Dote, Kensaku ^{[3
]}

Satou, Takao ^{[4
]}

Nishio, Kazuto ^{[5
]}

Fukuoka, Masahiro ^{[1
]}

Nakagawa, Kazuhiko ^{[1
]}

机构：

[1] Kinki Univ, Sch Med, Dept Med Oncol, Osaka 5898511, Japan

[2] Mitsubishi Chem Safety Inst Ltd, Kashima Lab, Res Div Adv Technol, Ibaraki, Japan

[3] Kinki Univ, Sch Med, Dept Pathol, Osaka 589, Japan

[4] Kinki Univ, Sch Med, Div Hosp Pathol, Osaka 589, Japan

[5] Kinki Univ, Sch Med, Dept Genome Biol, Osaka 589, Japan

来源：

LUNG CANCER | 2007年 / 58卷 / 03期

关键词：

EGFR mutation; non-small cell lung cancer; small cell lung cancer;

D O I：

10.1016/j.lungcan.2007.05.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a case of small cell lung cancer (SCLC) developing after prolonged treatment (more than 2 years) for primary adenocarcinoma of the lung, and we show that both the SCLC and non-small cell lung cancer (NSCLC) tissues obtained from the same site share the same deletion in exon 19 of EGFR. This case suggests that the activating EGFR mutations may confer the pathogenesis of a subset of SCLC. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：411 / 413

页数：3

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