Regulation of immune cell homeostasis by type I interferons

被引：35

作者：

Mattei, Fabrizio ^{[1
]}

Schiavoni, Giovanna ^{[1
]}

Tough, David F. ^{[2
]}

机构：

[1] Inst Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy

[2] GlaxoSmithKline, Immunoinflammat CEDD, Stevenage SG1 2NY, Herts, England

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2010年 / 21卷 / 04期

关键词：

Type I interferons; Homeostasis; T cells; Dendritic cells; HUMAN DENDRITIC CELLS; CD8(+) T-CELLS; HEMATOPOIETIC STEM-CELLS; CUTTING EDGE; IFN-ALPHA; LIFE-SPAN; DIRECT STIMULATION; CLONAL EXPANSION; IL-15; ANTIGEN;

D O I：

10.1016/j.cytogfr.2010.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although initially identified and best characterized for their role in innate antiviral defence, type I interferons (IFN-I) are also known to have an important impact on the adaptive immune response. In part, this is linked to another long-recognised property of IFN-I, namely their ability to modify cellular proliferation and survival. Here, we review the influence of IFN-I on immune cell homeostasis, focusing on their effects on T cells and antigen-presenting cells. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：227 / 236

页数：10

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