MMTV-like env gene sequences in human breast cancer

被引：55

作者：

Wang, Y

Pelisson, I

Melana, SM

Go, V

Holland, JF

Pogo, BGT

机构：

[1] CUNY Mt Sinai Sch Med, Dept Med, Div Med Oncol, New York, NY 10029 USA

[2] CUNY Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA

[3] CUNY Mt Sinai Sch Med, Dept Pathol, New York, NY 10029 USA

来源：

ARCHIVES OF VIROLOGY | 2001年 / 146卷 / 01期

关键词：

D O I：

10.1007/s007050170201

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have previously detected an MMTV env gene-like 660 bp sequence in 38% of human breast cancers, but not in normal tissues or other tumors. In this communication we report the sequences from eleven tumors and three breast cancer cell lines, and compare them to four strains of MMTV and to the known endogenous retroviral sequences. The breast cancer sequences were highly homogenous to the MMTV's, but not to the endogenous sequences suggesting an exogenous origin.

引用

页码：171 / 180

页数：10

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