A facile synthesis of trifluoromethylamines by oxidative desulfurization-fluorination of dithiocarbamates

被引：62

作者：

Kanie, K ^{[1
]}

Mizuno, K ^{[1
]}

Kuroboshi, M ^{[1
]}

Hiyama, T ^{[1
]}

机构：

[1] Tokyo Inst Technol, Resources Utilizat Res Lab, Midori Ku, Kanagawa 2268503, Japan

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1998年 / 71卷 / 08期

关键词：

D O I：

10.1246/bcsj.71.1973

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Trifluoromethylamines are easily synthesized from dithiocarbamates by a reagent system consisting of tetrabutylammonium dihydrogentrifluoride and an N-halo imide under mild conditions. When this reaction was applied to dithiocarbamates ArN(R)CS2Me at higher temperatures, the trifluoromethylation was accompanied by halogen substitution at the p-position of the Ar group. The synthesis of trifluoromethyl-substituted adenosine is also described.

引用

页码：1973 / 1991

页数：19

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