Sequential catalytic process:: synthesis of quinoline derivatives by AuCl3/CuBr-catalyzed three-component reaction of aldehydes, amines, and alkynes

被引：182

作者：

Xiao, Fengping ^{[1
]}

Chen, Yulin ^{[1
]}

Liu, Yu ^{[1
]}

Wang, Jianbo ^{[1
]}

机构：

[1] Peking Univ, BNLMS, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Coll Chem, Beijing 100871, Peoples R China

来源：

TETRAHEDRON | 2008年 / 64卷 / 12期

基金：

中国国家自然科学基金;

关键词：

catalysis; gold; quinoline; propargyl amine; alkyne; nucleophilic addition;

D O I：

10.1016/j.tet.2008.01.046

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A sequential catalytic process has been developed based on gold-catalyzed nucleophilic addition of terminal alkynes to imines, and gold-catalyzed intramolecular reaction of aromatic ring to alkynes. This one-pot reaction of aldehydes, amines, and alkynes gives quinoline derivatives in good yields. (C) 2008 Elsevier Ltd. All rights reserved.

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收藏

页码：2755 / 2761

页数：7

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