Phase I trial of docetaxel and cisplatin in previously untreated patients with advanced non-small-cell lung cancer

被引:69
作者
Millward, MJ
Zalcberg, J
Bishop, JF
Webster, LK
Zimet, A
Rischin, D
Toner, GC
Laird, J
Cosolo, W
Urch, M
Bruno, R
Loret, C
James, R
Blanc, C
机构
[1] PETER MACCALLUM CANC INST,EXPT CHEMOTHERAPY & PHARMACOL LAB,MELBOURNE,VIC 3000,AUSTRALIA
[2] AUSTIN & REPATRIAT MED CTR,DEPT ONCOL,HEIDELBERG,GERMANY
[3] RHONE POULENC RORER AUSTRALIA PTY LTD,KEW,AUSTRALIA
[4] RHONE POULENC,ANTONY,FRANCE
关键词
D O I
10.1200/JCO.1997.15.2.750
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: To determine the maximum-tolerance does (MTDs), principal toxicities, and pharmacokinetics of the combination of docetaxel and cisplatin administered every 3 weeks to patients with advanced non-small-cell lung cancer (NSCLC) who have not received prior chemotherapy and to recommend a dose of phase II studies. Patients and methods: Patients with advanced NSCLC and performance status 0 to 2 who have not received prior chemotherapy received docetaxel over 1 hour followed by cisplatin over 1 hour with hydration. Dose levels studied were (docetaxel/cisplatin) 50/75, 75/75, 75/100, and 100/75 mg/m(2) repeated every 3 weeks. Colony-stimulating factor (CSF) support was not used. Pharmacokinetics of docetaxel and cisplatin were studied in the first cycle of therapy. Most patients (79%) had metastic disease or intrathoracic recurrence after prior radiation and/or surgery. Results: Of 24 patients entered, all were assessable for toxicity and 18 for response. The MTD schedules were docetaxel 75 mg/m(2) with cisplatin 100 mg/m(2) (dose-limiting docetaxel toxicities [DLTs] in five of six patients), and docetaxel 100 mg/m(2) with cisplatin 75 mg/m(2) (DLTs in two of two patients, including one fatal toxicity). Limiting toxicities were febrile neutropenia and nonhematologic, principally diarrhea and renal. Two patients had neutropenic enterocolitis. Pharmacokinetics of both drugs were consistent with results from single-agent studies, which suggests no major pharmacokinetic interaction. Neutropenia was related to docetaxel area under the plasma concentration-versus-time curve (AUG). An alternative schedule was investigated, with cisplatin being administered over 3 hours commencing 3 hours after docetaxel, but toxicity did not appear to be less. Independently reviewed responses occurred in eight of 18 patients (44%; 95% confidence interval, 22% to 69%), most following 75 mg/m(2) of both drugs. Conclusion: Docetaxel 75 mg/m(2) over 1 hour followed by cisplatin 75 mg/m(2) over 1 hour is recommended for phase II studies. The responses seen in this phase I study suggest a high degree of activity of this combination in previously untreated advanced NSCLC. (C) 1997 by American Society of Clinical Oncology.
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页码:750 / 758
页数:9
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