Anaplastic lymphoma kinase in human cancer

被引：90

作者：

Barreca, Antonella ^{[1
,2
]}

Lasorsa, Elena ^{[1
,2
]}

Riera, Ludovica ^{[1
,2
]}

Machiorlatti, Rodolfo ^{[1
,2
]}

Piva, Roberto ^{[1
,2
,3
]}

Ponzoni, Maurilio ^{[4
]}

Kwee, Ivo ^{[5
,6
]}

Bertoni, Francesco ^{[5
,6
]}

Piccaluga, Pier Paolo ^{[7
]}

Pileri, Stefano A. ^{[7
]}

Inghirami, Giorgio ^{[1
,2
,3
]}

机构：

[1] Univ Turin, Dept Pathol, I-10126 Turin, Italy

[2] Univ Turin, CeRMS, I-10126 Turin, Italy

[3] NYU, Sch Med, NYU Canc Ctr, Dept Pathol, New York, NY 10016 USA

[4] Ist Sci San Raffaele, Unit Lymphoid Malignancies, I-20132 Milan, Italy

[5] Oncol Inst So Switzerland IOSI, Expt Oncol Lab, CH-6900 Bellinzona, Switzerland

[6] Oncol Inst So Switzerland IOSI, Lymphoma Unit, CH-6900 Bellinzona, Switzerland

[7] Univ Bologna, S Orsola Malpighi Hosp, Dept Hematol & Oncol Sci L&A Seragnoli, Hematopathol Sect, I-40138 Bologna, Italy

来源：

JOURNAL OF MOLECULAR ENDOCRINOLOGY | 2011年 / 47卷 / 01期

关键词：

LARGE-CELL LYMPHOMA; RECEPTOR TYROSINE KINASE; EML4-ALK FUSION GENE; INFLAMMATORY MYOFIBROBLASTIC TUMOR; SMALL-MOLECULE INHIBITOR; NON-HODGKINS-LYMPHOMA; HEAVY-CHAIN GENE; ALK FUSION; NPM-ALK; GROWTH-FACTOR;

D O I：

10.1530/JME-11-0004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The receptor tyrosine kinases (RTKs) play a critical role, controlling cell proliferation, survival, and differentiation of normal cells. Their pivotal function has been firmly established in the pathogenesis of many cancers as well. The anaplastic lymphoma kinase (ALK), a transmembrane RTK, originally identified in the nucleophosmin (NPM)-ALK chimera of anaplastic large cell lymphoma, has emerged as a novel tumorigenic player in several human cancers. In this review, we describe the expression of the ALK-RTK, its related fusion proteins, and their molecular mechanisms of activation. Novel tailored strategies are briefly illustrated for the treatment of ALK-positive neoplasms.

引用

页码：R11 / R23

页数：13

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