Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor

被引:241
作者
Nomura, T
Khan, MM
Kaul, SC
Dong, HD
Wadhwa, R
Colmenares, C
Kohno, I
Ishii, S [1 ]
机构
[1] RIKEN, Tsukuba Life Sci Ctr, Mol Genet Lab, Tsukuba, Ibaraki 3050074, Japan
[2] Agcy Ind Sci & Technol, Natl Inst Biosci & Human Technol, Tsukuba, Ibaraki 3050046, Japan
[3] Chugai Res Inst Mol Med, Niihari, Ibaraki 3004101, Japan
[4] Cleveland Clin Fdn, Lerner Res Inst, Dept Canc Biol, Cleveland, OH 44195 USA
[5] Iatron Labs Inc, Chiba 2892247, Japan
关键词
Ski; N-CoR/SMRT corepressor; mSin3; Mad; histone deacetylase complex;
D O I
10.1101/gad.13.4.412
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The N-CoR/SMRT complex containing mSin3 and histone deacetylase (HDAC) mediates transcriptional repression by nuclear hormone receptors and Mad. The proteins encoded by the ski proto-oncogene family directly bind to N-CoR/SMRT and mSin3A, and forms a complex with HDAC. c-Ski and its related gene product Sno are required for transcriptional repression by Mad and thyroid hormone receptor (TR beta). The oncogenic form, v-Ski, which lacks the mSin3A-binding domain, acts in a dominant-negative fashion, and abrogates transcriptional repression by Mad and TR beta. In ski-deficient mouse embryos, the ornithine decarboxylase gene, whose expression is normally repressed by Mad-Max, is expressed ectopically. These results show that Ski is a component of the HDAC complex and that Ski is required for the transcriptional repression mediated by this complex. The involvement of c-Ski in the HDAC complex indicates that the function of the HDAC complex is important for oncogenesis.
引用
收藏
页码:412 / 423
页数:12
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