Effects of Gabapentin and Topiramate in primary rat astrocyte cultures

被引：25

作者：

Cardile, V

Pavone, A

Renis, M

Maci, T

Perciavalle, V

机构：

[1] Univ Catania, Dept Physiol Sci, I-95125 Catania, Italy

[2] Univ Catania, Dept Biochem, I-95125 Catania, Italy

[3] Garibaldi Hosp, Dept Neurol, I-95123 Catania, Italy

来源：

NEUROREPORT | 2001年 / 12卷 / 08期

关键词：

AEDs; cell viability; glial cells; glutamine synthetase; nitric oxide; oxidative stress;

D O I：

10.1097/00001756-200106130-00037

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied in vitro the effects of anticonvulsant drugs Gabapentin and Topiramate on the production of reactive oxygen species and nitric oxide (NO), the activity of glutamine synthetase (GS), and cell viability in primary cultures of rat cortical astrocytes which are intimately involved in the normal functioning of neurons. We investigated the effects of these drugs at concentrations within the therapeutic range (1, 10 and 50 mug/ml). We observed that, in cultured astrocytes, Gabapentin induced a weak increase in the biosynthesis of NO, a mild decrease in GS activity and cell viability, and minor induction of a stress condition. Topiramate was observed to induce even greater stressor effects on these cells. NeuroReport 12:1705-1708 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：1705 / 1708

页数：4

共 18 条

[1] Tripartite synapses: glia, the unacknowledged partner [J].