The parkin gene is not involved in late-onset Parkinson's disease

被引：32

作者：

Oliveri, RL

Zappia, M

Annesi, G

Bosco, D

Annesi, F

Spadafora, P

Pasqua, AA

Tomaino, C

Nicoletti, G

Pirritano, D

Labate, A

Gambardella, A

Logroscino, G

Manobianca, G

Epifanio, A

Morgante, L

Savettieri, G

Quattrone, A

机构：

[1] Univ Catanzaro, Neurol Inst, Catanzaro, Italy

[2] Natl Res Council, Inst Expt Med & Biotechno, Piano Lago di Mangone, CS, Italy

[3] Osped Miulli, Acquaviva delle Fonti, BA, Italy

[4] Univ Messina, Inst Neurol, I-98100 Messina, Italy

[5] Univ Palermo, Inst Neurol, I-90133 Palermo, Italy

来源：

NEUROLOGY | 2001年 / 57卷 / 02期

关键词：

D O I：

10.1212/WNL.57.2.359

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Mutations in the parkin gene have been reported in patients with early onset PD. The authors investigated the parkin gene in 118 patients who had an onset of PD after age 45 years: 95 subjects were sporadic patients and 23 subjects were from 18 families with a probable autosomal recessive inheritance. No pathogenetic mutations in the parkin gene were detected either in familial or in sporadic patients. Moreover, no differences were found between patients and 100 age-matched normal controls in the allele and genotype frequencies of four exonic parkin polymorphisms.

引用

页码：359 / 362

页数：4

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