Total serum IgE levels in a large cohort of patients with severe or difficult-to-treat asthma

Background: Limited data are available on levels of IgE in large cohorts of patients with severe or difficult-to-treat asthma. Objective: To examine IgE levels and disease in patients from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. Methods: From January 2001 to October 2001, 4,923 patients were screened for inclusion in the study. Of these, 4,756 patients 6 years or older with severe or difficult-to-treat asthma were enrolled and completed a baseline study visit. Total serum IgE levels were measured at the baseline visit and are summarized by geometric means. Results: The mean total IgE level of the population is 106.6 IU/mL (95% confidence interval, 101.5-112.0 IU/mL). Children (6-12 years old) and adolescents (13-17 years old) have higher mean IgE levels than adults (>= 18 years old) (P<.001). Males have a higher mean IgE level than females (P< .001). IgE levels are higher among nonwhite patients than white patients (P <.001). Current smokers have higher IgE levels than past smokers or never smokers (P<.001). Among children, patients with 7 severe asthma have a higher mean IgE level (280.2 IU/mL) than patients with moderate (145.8 IU/mL) or mild (137.8 IU/mL) asthma (P<.001). Among adults, patients with childhood-onset asthma have higher IgE levels (124.3 IU/mL [n = 1,348]) than patients with adult-onset asthma (65.7 IU/mL [n = 1,956]) (P< .001). Conclusion: In patients with severe or difficult-to-treat asthma from, the TENOR study, higher total IgE levels were observed in males, children, smokers, nonwhite racial/ethnic groups, and adults with childhood-onset disease. In addition, IgE levels are associated with asthma severity among younger patients.