Chronic intracerebroventricular infusion of angiotensin II increases brain AT1 receptor expression in young rats

被引：20

作者：

Porter, JP ^{[1
]}

机构：

[1] Brigham Young Univ, Dept Zool, Provo, UT 84602 USA

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1999年 / 112卷 / 02期

关键词：

angiotensin II; AT1; receptor; hypertension; rat;

D O I：

10.1016/S0165-3806(98)00182-5

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The aim of the present study was to determine the effect of chronic intracerebroventricular infusion of angiotensin II (ANG II) on the expression of brain AT1 receptors in young (3-4 weeks) rats. One week of icy ANG II infusion produced a significant increase in brain AT1 receptor protein (Western blot) and mRNA (relative RT-PCR) expression. These data raise the possibility that ANG II may play a role in postnatal expression of brain AT1 receptors. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：293 / 295

页数：3

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