Meta-Analysis of Cytokines and Chemokines in Suicidality: Distinguishing Suicidal Versus Nonsuicidal Patients

被引:314
作者
Black, Carmen [1 ]
Miller, Brian J. [2 ]
机构
[1] Georgia Regents Univ, Med Coll Georgia, Augusta, GA 30912 USA
[2] Georgia Regents Univ, Dept Psychiat & Hlth Behav, Augusta, GA 30912 USA
基金
美国国家卫生研究院;
关键词
Chemokines; Cytokines; Depression; Inflammation; Meta-analysis; Suicide; MAJOR DEPRESSIVE DISORDER; CHOLINERGIC ANTIINFLAMMATORY SYSTEM; ENDOTHELIAL GROWTH-FACTOR; CEREBROSPINAL-FLUID; BIPOLAR DISORDER; TNF-ALPHA; ACTIVATION; PLASMA; BLOOD; RISK;
D O I
10.1016/j.biopsych.2014.10.014
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
BACKGROUND: Major psychiatric disorders are associated with inflammation. Aberrant cytokine and chemokine levels have been associated with psychiatric disorders and suicidal behavior. We performed a meta-analysis of cytokine and chemokine levels in patients with versus without suicidality and patients with suicidality versus healthy controls. METHODS: We identified articles by searching MEDLINE, PsycINFO, and Thomson Reuters Web of Knowledge databases and the reference lists of identified studies. RESULTS: Study inclusion criteria were met by 18 studies comprising 583 patients with suicidality, 315 patients without suicidality, and 845 healthy control subjects. Levels of interleukin (IL)-1 beta and IL-6 were significantly increased in blood and postmortem brain samples of patients with suicidality compared with both patients without suicidality and healthy control subjects (p < .05 for each). In vitro IL-2 production by peripheral blood mononuclear cells was significantly decreased in patients with suicidality compared with both patients without suicidality and healthy controls (p < .01 for each). Cerebrospinal fluid levels of IL-8 were significantly decreased in patients with suicidality versus control subjects (p < .05). CONCLUSIONS: We found evidence for aberrant cytokine levels in blood, cerebrospinal fluid, and postmortem brain samples of patients with suicidality. Levels of IL-1 beta and IL-6 were most robustly associated with suicidality, and these cytokines may help distinguish suicidal from nonsuicidal patients. Rigorously designed longitudinal studies are needed to evaluate these associations further.
引用
收藏
页码:28 / 37
页数:10
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