Polo-like kinase (Plk) 1 as a target for prostate cancer management

被引：20

作者：

Reagan-Shaw, S ^{[1
]}

Ahmad, N ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Dermatol, Madison, WI 53706 USA

来源：

IUBMB LIFE | 2005年 / 57卷 / 10期

关键词：

Plk1; prostate cancer; chemoprevention;

D O I：

10.1080/15216540500305910

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prostate cancer (PCa) is the most commonly occurring cancer in American men, next to skin cancer. Existing treatment options and surgical intervention are unable to effectively manage this cancer. Therefore, continuing efforts are ongoing to establish novel mechanism-based targets and strategies for its management. The serine/threonine kinases Polo-like kinase (Plk) 1 plays a key role in mitotic entry of proliferating cells and regulates many aspects of mitosis which are necessary for successful cytokinesis. Plk1 is overexpressed in many tumor types with aberrant elevation frequently constituting a prognostic indicator of poor disease outcome. This review discusses the studies which indicate that Plk1 could be an excellent target for the treatment as well as chemoprevention of prostate cancer.

引用

页码：677 / 682

页数：6

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