Mechanical properties of rat thoracic and abdominal aortas

Mechanical properties of abdominal and thoracic arteries of 2 turn in diameter were determined from adults Wistar rats. A tensile testing instrument was used to obtain stress/strain curves with arteries immersed in physiological buffer at 37 degrees C. A displacement was applied on all arteries with various frequencies (1-7.5 Hz) and strains (5-60%). From each Curve a Young modulus was obtained using a mathematical model based on a nonlinear soft tissue model. No influence of frequency on modulus was evidenced in the tested range. Abdominal aortas, which were found slightly thicker than thoracic aortas, were characterized by a higher modulus. Due to the interest of decellularized biological materials, We also used SDS/Triton treated arteries, and found that the chemical treatment increased modulus Of thoracic arteries. Tensile tests were also performed on thoracic aortas in the longitudinal and transversal directions. Longitudinal moduli Were found higher than transversal moduli and the difference Could be related to the longitudinal orientation of collagen fibers. These data and mathematical model Seem useful in the design of new vascular Synthetic or biological prostheses for the field Of tissue engineering. (C) 2008 Elsevier Ltd. All rights reserved.